Library research guide to education: illustrated search strategy and sources Essay

atomic number 11 supports the proper functioning of the nerves by playing its role in action potentials action potentials atomic number 18 electrical impulses sent when the nerve cellular telephones receive signals down the length of the cells hence triggering communication with the neighboring cells. During the action potentials, atomic number 11 ions rushes out of the nerve cells to initiate electrochemical impulse (Budvytyte et al, 2014).Why is this accession relevant or useful to understanding the loss of function in neurons?This approach is useful to understand neurons loss of functions because lack of atomic number 11 in the blood hinders the communication of the nerves, hence deficiency of sodium can topic to muscle cramps because of abnormal communication between the muscle fibers and the nerves (Budvytyte et al, 2014). mentality 2What is the normal preoccupancy gradient of sodium in the noisome system (should the sodium concentration be higher(prenominal)(prenomin al) or subvert within the cell comp atomic number 18d to the extracellular tranquil)?For a resting neuron, there is high concentration of chlorine and sodium ions in the extracellular fluid than the intracellular fluid. However, in the intracellular fluids, there is high concentration of potassium compared to the extracellular fluid (Madelin et al, 2010).How does the flip in the sodium concentration detected from MRI of the genus Hippocampus suggest that the neurons in the hippocampus became diseased and were not functioning flop?To detect a neuron death, sodium MRI tomography is utilize. The higher sodium (Na+) concentration indicate that there were dead or alter cells. When making comparisons of the two images of the control patients and the Alzheimer brain, brighter areas are seen in the Alzheimer patent brain than the control patient. This is an indication of higher concentration levels of sodium and indicates dysfunction of neurons. out front the death of cells, the in creased levels of sodium in the tissue could be as a result of sodium direct leak because if the Na/K ATPase retro-gradation or amyloid beta channels (Mellon et al, 2009).What sort of a change in the Na+ concentration gradient would you expect when neurons are shamed or malfunctioning?Only a small intracellular sodium increase would be expected to produce signal long suit change. afterward the death of the neurons, the infinite I the intracellular shrinks and the extra cellular space expands. More everyplace, the extra cellular space will have a extended concentration of sodium which produce a large signal intensity of sodium (Mellon et al, 2009).Question 4The partner reviewed article on Sodium MR imaging detection of flabby Alzheimer disease discusses how the changes in the concentration of sodium detected from the hippocampus MRI suggest that the hippocampus neuron became diseased and does not functioning properly.The article about bring through Potential meeting in Nerves discusses the action Potential Collision in Nerves. I used the article in this assignment to understand what role sodium play in neuronal action.This article Sodium MRI with tercet Quantum get across and Inversion Recovery at 7T is about the current cognizance in NNR in in medicine. I used the article in understanding the differences in the relative concentrations of sodium (Na+) in the hippocampus employ magnetic resonance imaging (MRI).5. In what ways are the studies akin in their method and conclusions?All the three studies used experimental methodology in their re attempt design. Moreover, in their conclusions, there were similarity since all of them prove their hypothesis in relation to sodium innerves.In what ways are the studies different in their method and conclusions?The three studies used different equipment in their data collection. For instance, in the study of Sodium MR imaging detection of mild Alzheimer disease, used 3T clinical scanner, in the study Sodium M RI with multiply Quantum Filter and Inversion Recovery at 7T, used 7T Whole soundbox Scanner and a single tuned Na head coil.Question 7What some other observations might we expect to find in references with similar issues?The other observations expected to be found include using sodium imaging as a clinical tool in detecting neuropathologic changes that are related with Alzheimer diseaseWhat would we want to look for in the future, now that we realize what this case has taught us?In future, we would want to look for the implementation of IR23NaMRI and TQR fir the human brain at 7T in vivo in order to judge the intracellular concentration of sodium.Question 8Give your resultant role of the case What does it tell us about autopoiesis in human anatomy and physiology?My resolution is that the case is that there is a dysfunction in the neurons or cell death because of the brighter areas on the patients brain. Brighter areas are an indication of higher concentration levels of sodi um on the neurons that have dysfunctionalOn a scale of 15, rate how confident you are in your conclusions in questions 1 and 2.I would rate my conclusions at 5Question 9Describe how you located the information you used in this case.To begin the search, I started with the most comprehensive data base that is Cumulative Index to nursing and Allied Health (NINAH) (Kennedy 2009). The search then continued to search engines much(prenominal) as British Nursing Index, MEDLINE. Moreover PubMed and NCBI were other major search engines which assisted some of the relevant articles. These search engines were used because they contained most of the peer review articles and books. To limit and narrow down the search for articles, internal searches of the databases was used by inserting full length of texts and searching the relevant articles from the list of journals displayed. Moreover, I limited myself to the current articles of up to 5 yearsIf you had it to do over again, what you might do d ifferently?I would use different resources to bring on different information so as to make comparisons of different studiesReferencesBudvytyte, R., Gonzalez-Perez, A., Mosgaard, L., & Heimburg, T. (January 01, 2014). Action Potential Collision in Nerves. Biophysical Journal, 106, 2.)G. Madelin, N. Oesingmann, G. Johnson, A. Jerschow, and M. Inglese (2010). Sodium MRI with Triple Quantum Filter and Inversion Recovery at 7T. ONLINE Available at http//www.google.com/universal resource locator?sa=t&rct=j&q=&esrc=s&source=web&cd=1&ved=0CCcQFjAA&url=http%3A%2F%2Fwww.med.nyu.edu%2Fradiology_research%2Fassets%2F03251.pdf&ei=tTyNVJmdH9GcugS5lYCIAw&usg=AFQjCNEbJrsrWJx0NrRJ0UjQSQ7y7IPJtA&sig2=4GdWwL6yW-a0Obj6LLMEmA&bvm=bv.81828268,d.c2E. Last Accessed 14th November 2014.Kennedy, J. R. (2009). Library research guide to education illustrated search system and sources. Ann Arbor, Mich, Pierian Press.Mellon, E. A., Pilkinton, D. T., Clark, C. M., Elliott, M. A., Witschey, W. R. ., Borthakur, A., & Reddy, R. (January 01, 2009). Sodium MR imaging detection of mild Alzheimer disease preliminary study. Ajnr. American Journal of Neuroradiology, 30, 5, 978-84. Retrieved from http//www.ncbi.nlm.nih.gov/pmc/articles/PMC2866317/Source document